WHAT MIGHT BE THE DIFFERENCE IN VIRAL PROTEINS?

Akila K.¹, Rajasekaran E.²*
¹Department of Bioinformatics, Jamal Mohamed College, Trichy – 620020
²Department of Biotechnology, Periyar Maniammai University, Vallam, Thanjavur – 613403
* Corresponding Author : ersekaran@gmail.com

Received : -     Accepted : -     Published : 21-12-2009
Volume : 1     Issue : 2       Pages : 1 - 3
Int J Bioinformatics Res 1.2 (2009):1-3
DOI : http://dx.doi.org/10.9735/0975-3087.1.2.1-3

Keywords : carbon distribution, arenaviruses, theoretical study, sequence analysis
Conflict of Interest : None declared

The difference between normal and viral proteins is the way the amino acids organized in some form. Though both proteins use same 20 naturally occurring amino acids, it differs in arrangements. This difference cannot be felt by merely comparing the amino acid sequence but at atom level. This is analysed and compared in terms of carbon distribution as carbon is the only element that contributes towards the dominant force, hydrophobic interaction. For this purpose the arenaviruses have been selected here for study. The protein sequences of 7 arenaviruses are analysed. Our results show that the carbon distribution in viral proteins is different from the normal proteins. Either the carbon content is different or the distribution is not uniform. This carbon distribution analysis uses our earlier report of 31.44% of carbon for its structure and activity.

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