Phylogenetic signatures of functional conservedness in lantibiotics- an in-silico regulomics study

Sayak Ganguli¹*, Protip Basu², Hirak Jyoti Chakraborty³, Paushali Roy⁴, Abhijit Datta^5
1DBT-Centre for Bioinformatics, Presidency College, Kolkata
²DBT-Centre for Bioinformatics, Presidency College, Kolkata
³DBT-Centre for Bioinformatics, Presidency College, Kolkata
⁴DBT-Centre for Bioinformatics, Presidency College, Kolkata
⁵DBT-Centre for Bioinformatics, Presidency College, Kolkata
* Corresponding Author : sayakbif@yahoo.com

Received : -     Accepted : -     Published : 21-12-2010
Volume : 2     Issue : 2       Pages : 5 - 11
Int J Microbiol Res 2.2 (2010):5-11
DOI : http://dx.doi.org/10.9735/0975-5276.2.2.5-11

Conflict of Interest : None declared

The name Lantibiotics was introduced in 1988 as an abbreviation for "Lanthionine-containing peptide antibiotics". In spite of this naming, Lantibiotics are not classed as antibiotics. The first structures of these antimicrobial agents were produced by pioneering work by Gross and Morell in the late sixties and early seventies, thus marking the formal introduction of Lantibiotics. Since then Lantibiotics such as Nisin have been for food preservation and have yet to encounter significant bacterial resistance. These attributes of lantibiotics have led to more detailed research into them.

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