THYROID FUNCTION TESTS IN NIGERIAN HIV SERO- POSITIVE PATIENTS ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)

ABBIYESUKU F.M.¹, OSUJI K.C.²*, KUTI M.O.³, ATIBA A.S.^4
1Department of Chemical Pathology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo State, Nigeria.
²Department of Chemical Pathology, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
³Department of Chemical Pathology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo State, Nigeria.
⁴Department of Chemical Pathology, Ekiti State University, Ado-Ekiti, Nigeria.
* Corresponding Author : iji70@hotmail.com

Received : 21-02-2014     Accepted : 27-03-2014     Published : 09-06-2014
Volume : 5     Issue : 1       Pages : 277 - 281
Int J Med Clin Res 5.1 (2014):277-281
DOI : http://dx.doi.org/10.9735/0976-5530.5.1.277-281

Keywords : Thyroid function test, Human immunodeficiency virus (HIV), free T4, free T3, Thyroid Stimulating Hormone
Conflict of Interest : None declared

Background: Recent studies suggest that the prevalence of hypothyroidism among human immunodeficiency virus (HIV) people who were on treatment with highly active antiretroviral therapy (HAART) was higher than that in treatment naïve HIV infected people and those who were not infected with HIV. Objective: This study was to determine thyroid function test in HIV infected people on various regimen of HAART. Subjects and Methods: A total of 128 participants were randomly recruited for the study. Seventy six were HIV positive on HAART, 24 were HIV positive but treatment-naïve and HIV negative population was 28. Blood samples were collected from each study group for thyroid stimulating hormone (TSH), free thyroxine (FT₄) and free triiodothyronine (FT₃). A chemiluminescence based third generation thyroid assay was used for the analysis of these parameters. Result: Free T3 and fT4 were observed to be significantly lower in HIV positive patients whether on HEART or not than those that were HIV-negative (p>0.001 and p=0.014). Correspondingly, TSH was found to be significantly higher in test groups than normal HIV-negative control, p<0.001. Conclussion: There is no difference in thyroid function test among HIV infected people, whether treatment naïve or on HAART. However, thyroid hormones (fT3, fT4) was lower in HIV positive patients than HIV-negative controls.

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