IDENTIFICATION OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE RESISTANCE IN PATHOGENIC AND NON-PATHOGENIC BACTERIA : BIOINFORMATICS ANALYSIS ON NON-CODING MOTIF

SRIVASTAVA A.¹, GUPTA D.^2
1Center of Bioinformatics, Institute of Interdisciplinary Studies, University of Allahabad, Allahabad- 211 002, UP, India.
²Department of Biochemistry, University of Allahabad, Allahabad- 211 002, UP, India.

Received : 28-11-2013     Accepted : 18-12-2013     Published : 27-12-2013
Volume : 1     Issue : 1       Pages : 21 - 24
World Res J Bioinformatics 1.1 (2013):21-24

Conflict of Interest : None declared

The treatment of infections is frustrating as it is increasingly compromised by the ability of bacteria to develop resistance towards antibiotics through mutations or through acquisition of resistance gene. Both pathogenic and non-pathogenic bacteria belonging to class gram- and gram⁺, like Mycobacterium tuberculosis, Lactobacillus reuter, Streptococcus pneumonia and a host of others show resistance towards aminoglycoside phosphotransferase (AGPT) activity. In the present study we have conducted an in silico study on the gene that confers resistance towards AGPT. The bioinformatics based study heads in the direction of developing a novel motif from sequences (taken from NCBI) of gene against AGPT taken from ARDB (Antibiotic Resistance Gene Database). We have observed a motif that could potentially be used for developing drugs.