S-layer proteins from lactobacilli as vaccine delivery systems

Axel Hollmann; Lucrecia Delfederico; Anderson Miyoshi; Edgardo Anibal Disalvo; Graciela De Antoni; Liliana Semorile; Vasco Azevedo

doi:http://dx.doi.org/10.9735/0975-5276.2.2.30-43

S-layer proteins from lactobacilli as vaccine delivery systems

Axel Hollmann¹*, Lucrecia Delfederico², Anderson Miyoshi³, Edgardo Anibal Disalvo⁴, Graciela De Antoni⁵, Liliana Semorile⁶, Vasco Azevedo⁷
¹Laboratorio de MicrobiologÃa Molecular, Departamento de Ciencia y TecnologÃa, Universidad Nacional de Quilmes, Bernal, Argentina
²Laboratorio de MicrobiologÃa Molecular, Departamento de Ciencia y TecnologÃa, Universidad Nacional de Quilmes, Bernal, Argentina
³Instituto de CiÃªncias BiolÃ³gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil
⁴Laboratorio de FisicoquÃmica de Membranas LipÃdicas y Liposomas, CÃ¡tedra de QuÃmica General e InorgÃ¡nica, Facultad de Farmacia y BioquÃmica, Universidad de Buenos Aires, Buenos Aires, Argentina
⁵Centro de InvestigaciÃ³n y Desarrollo en CriotecnologÃa de Alimentos (CIDCA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
⁶Laboratorio de MicrobiologÃa Molecular, Departamento de Ciencia y TecnologÃa, Universidad Nacional de Quilmes, Bernal, Argentina
⁷Instituto de CiÃªncias BiolÃ³gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil
* Corresponding Author : ahollmann@gmail.com

Received : - Accepted : - Published : 21-12-2010
Volume : 2 Issue : 2 Pages : 30 - 43
Int J Microbiol Res 2.2 (2010):30-43
DOI : http://dx.doi.org/10.9735/0975-5276.2.2.30-43

Keywords : S-layer proteins, lactobacilli, oral delivery, liposomes, vaccine design
Conflict of Interest : None declared

Cite - MLA : Axel Hollmann, et al "S-layer proteins from lactobacilli as vaccine delivery systems." International Journal of Microbiology Research 2.2 (2010):30-43. http://dx.doi.org/10.9735/0975-5276.2.2.30-43

Cite - APA : Axel Hollmann, Lucrecia Delfederico, Anderson Miyoshi, Edgardo Anibal Disalvo, Graciela De Antoni, Liliana Semorile, Vasco Azevedo (2010). S-layer proteins from lactobacilli as vaccine delivery systems. International Journal of Microbiology Research, 2 (2), 30-43. http://dx.doi.org/10.9735/0975-5276.2.2.30-43

Cite - Chicago : Axel Hollmann, Lucrecia Delfederico, Anderson Miyoshi, Edgardo Anibal Disalvo, Graciela De Antoni, Liliana Semorile, and Vasco Azevedo "S-layer proteins from lactobacilli as vaccine delivery systems." International Journal of Microbiology Research 2, no. 2 (2010):30-43. http://dx.doi.org/10.9735/0975-5276.2.2.30-43

Copyright : © 2010, Axel Hollmann, et al, Published by Bioinfo Publications. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

The S-layer, crystalline arrays of proteinaceous subunits, seems to be a typical surface structure in several lactobacilli species. Due their self-assembly ability to recrystallize into isoporous monolayers in suspension, at liquid-surface interfaces, lipid structures and on solid supports, S-layers were demonstrated to possess a great potential for nanobiotechnological applications. Interest in lactobacilli S-layer has been reinforced by claimed and demonstrated probiotic properties for human and animal consumers. Several lactobacillar S-layer have been found to be involved in adherence to intestinal epithelial cells and to the mammalian extracellular matrix. Due to these observed adhesive properties, the possible therapeutic applications of lactobacillar S-layers have become increasingly of interest, e.g. as targeted antigen delivery vehicles to host tissues. In addition, S-layers may provide superior expression levels and surface density of antigens when compared to other bacterial antigen presentation systems. It has already been demonstrated that S-layer protein subunits can be modified to carry foreign epitopes as a uniform recombinant S-layer on the Lactobacillus cell surface. The adhesion and immunogenic functions of S-layer proteins, combined with the properties of Lactobacillus spp., could lead to new, safe, and stable liposomal particles for drug delivery.

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