Induction of apoptosis by the aqueous and ethanolic leaf extract of Vitex negundo L. in MCF-7 human breast cancer cells

Arulvasu C.¹*, Prabhu D.², Manikandan R.³, Srinivasan P.⁴, Dinesh D.⁵, Babu G.⁶, Sellamuthu S.^7
1Department of Zoology, University of Madras, Chennai, 600025, Tamil Nadu, India
²Department of Zoology, University of Madras, Chennai, 600025, Tamil Nadu, India
³Department of Animal Health and Management
⁴Department of Bioinformatics, Alagappa University, Karaikudi, 630003, Tamil Nadu, India
⁵Department of Zoology, University of Madras, Chennai, 600025, Tamil Nadu, India
⁶Department of Zoology, University of Madras, Chennai, 600025, Tamil Nadu, India
⁷Department of Zoology, University of Madras, Chennai, 600025, Tamil Nadu, India
* Corresponding Author : carulvasu@gmail.com

Received : -     Accepted : -     Published : 15-06-2010
Volume : 2     Issue : 1       Pages : 1 - 7
Int J Drug Discov 2.1 (2010):1-7
DOI : http://dx.doi.org/10.9735/0975-4423.2.1.1-7

Keywords : Anti-cancer, anti-proliferative, breast cancer, cytotoxicity, V. negundo, MCF-7
Conflict of Interest : None declared
Acknowledgements/Funding : The authors acknowledge the National Centre for Cell Science (NCCS), Pune for providing cancer cell lines

The aim of this investigation was to evaluate the anti-proliferative potential of aqueous and ethanolic extract from Vitex negundo against human breast cancer cell (MCF-7). The aqueous and ethanol extract from V. negundo potently inhibited growth of MCF-7 in a concentration-dependent manner. V. negundo pretreatment resulted in deferential cell viability and IC50 value were observed in MCF-7 cell line but not in control cell line. The above result suggested that V. negundo has a potential benefits in breast cancer cells.

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